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The Children’s Cancer Therapy Development Institute is collaborating with Champions Oncology and The Jackson Laboratory to provide RACE Act/PREA pediatric cancer study plan services

January 29, 2020 GMT
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The Children's Cancer Therapy Development Institute (cc-TDI), Champions Oncology, and The Jackson Laboratory offer rapid, cost-effective services to the pharma, biopharma and biotech industry- speeding the right drug to the right pediatric cancer ...
1 of 5
The Children's Cancer Therapy Development Institute (cc-TDI), Champions Oncology, and The Jackson Laboratory offer rapid, cost-effective services to the pharma, biopharma and biotech industry- speeding the right drug to the right pediatric cancer ...

The Children’s Cancer Therapy Development Institute (cc-TDI), Champions Oncology, and The Jackson Laboratory offer rapid, cost-effective services to the pharma, biopharma and biotech industry- speeding the right drug to the right pediatric cancer whenever possible.

HACKENSACK, NJ and BAR HARBOR, ME / ACCESSWIRE / January 29, 2020 / The Children’s Cancer Therapy Development Institute (cc-TDI) is collaborating with Champions Oncology (NASDAQ:CSBR) and The Jackson Laboratory (JAX) to provide end-to-end bioinformatics, lab-based and xenograft solutions for pediatric preclinical study packages.

Jordyn (in pink) with her family. Jordyn is a childhood cancer survivor, but less than half of the children with her type of cancer can attain a cure. For this kind of cancer only one new drug has shown activity since 1972, and no drugs have proven effective enough to earn FDA approval in the last 50 years.

Champions Oncology, The Jackson Laboratory, and cc-TDI share the same goal as every parent, scientist, and clinical investigator: to get the right drug to treat the specific type of pediatric cancer, ultimately improving outcomes.

As a result of the RACE for Children Act (Research to Accelerate Cures and Equity for Children Act) any targeted cancer drug in developmentwill now be developed for both adults and children. The goal of this legislative requirement is to balance the scales as adult cancer averages twelve or more drugs earning FDA approval each year, yet pediatric cancer has only received eight FDA approvals since 1978.

By working with Champions Oncology and The Jackson Laboratory, cc-TDI is able to bring their domain expertise to offer turnkey preclinical studies that are required of Phase 2 adult oncology drugs that will move to phase 3 clinical trials. Despite RACE Act legislation, many pharmaceutical companies will not have resources to attribute to pediatric cancer-specific basic science and translational (preclinical/animal model) R&D. The turnkey services offered by this consortium will create a virtual pediatric cancer research and development group for any pharmaceutical company seeking compliance and/or opportunities for childhood cancer drug development. These pediatric preclinical study plan packages span bioinformatics from in vitro to in vivo studies.

“Knowing that the industry-wide need for pediatric study plans will be high, Champions Oncology, The Jackson Laboratory and cc-TDI are committed to helping pharmaceutical companies select the drugs with greatest promise for further pediatric study, or to rule out drugs without appreciable pediatric indications (thereby increasing the availability of new agents to children with cancer via clinical trials)”, said Charles Keller MD, scientific director of cc-TDI.

Dr. Ronnie Morris, CEO of Champions Oncology remarked, “We appreciate that the decision to take an oncology drug from phase II to phase III trials is often done leaving as little as six months to determine what pediatric cancer might apply (with respect to RACE Act guidelines). By utilizing our unique tumor bank with many pediatric cancer models, we can facilitate preclinical studies in an accelerated and time-efficient manner.”

“JAX is a pioneer in genetics and mouse model development. We maintain the world’s largest and diverse collection of mouse models that better represent the genetic and biological complexity of human disease,” said Dr. James Keck, senior director of Innovation and Product Development, The Jackson Laboratory. “Our mission is to support the scientific community by providing these tools and leverage our 90 years of expertise to design and perform preclinical studies. We are thrilled to work with The Children’s Cancer Therapy Development Institute as we have a longstanding commitment to pediatric cancer research, and the pediatric, adolescent, and young adult mouse models that we have developed are well-suited to the preclinical studies now required by the RACE for Children Act.”

About Champions Oncology, Inc.:

Champions Oncology ( www.ChampionsOncology.com ) (NASDAQ: CSBR) is a leading global oncology pharmacology services provider. US-based, we utilize our experience in clinically relevant models of cancer and assist biopharmaceutical companies of all sizes across all stages of drug development. Our mission is to provide translational solutions that enable the assessment of drug effectiveness and identification of relevant patient populations to target in human clinical trials. With an extensive and well-characterized Patient Derived Xenograft bank across a wide range of indications, Champions is well positioned to run proof-of-concept, indication expansion and clinical trial simulation studies. Models are available with patient clinical data, including patient treatment and response information, in addition to Whole Exome and RNA Sequencing data. Standard of care responses have also been generated in vivo for a large number of models. These models include more than 150 pediatric, adolescent and young adult patient-derived xenografts models representing leukemias (ALL, AML), brain tumors (malignant glioma, ETANTR/EMTR), hepatoblastoma, teratoma/malignant germ cell tumor and sarcoma (osteosarcoma, rhabdomyosarcoma, synovial sarcoma, spindle cell sarcoma, Ewing sarcoma, DSRCT, UPS, fibrosarcoma, MPNST, chordoma, myoepithelioma, liposarcoma and salivary carcinoma.

Press Contact:

Rachel Bunting, MS, MBA

Sr. Director, Head of Marketing

Official Homepage: www.championsoncology.com

Facebook: https://www.facebook.com/championsoncology/

LinkedIn: https://www.linkedin.com/company/champions-oncology-inc-/

About The Jackson Laboratory:

The Jackson Laboratory (JAX) is an independent, nonprofit biomedical research institution with more than 2,200 employees. Headquartered in Bar Harbor, Maine, it has a National Cancer Institute-designated Cancer Center, a genomic medicine institute in Farmington, Conn., and facilities in Ellsworth, Maine, Sacramento, Calif., and Shanghai, China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies its nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and empowers the global biomedical community by providing critical data, tools and services. JAX is the world’s source for more than 11,000 strains of genetically defined mice, is home of the Mouse Genome Informatics and Mouse Phenome databases, and is a hub for scientific courses, conferences, training and education.

With ever-increasing precision, JAX identifies the genetic and molecular bases of disease and marshals its strengths in genomics and modeling to discover individualized treatments and cures. Their work will make medicine more precise, predictable and personal, improving care, lowering costs and increasing life span and health span.

For more information, please visit www.jax.org.

Press Contact:

Sarah Laskowski

Senior Manager, Public Relations

Email:

Official Homepage: www.jax.org

Twitter: https://twitter.com/jacksonlab

Facebook: https://www.facebook.com/JacksonLaboratory/

LinkedIn: https://www.linkedin.com/company/the-jackson-laboratory/

About The Children’s Cancer Therapy Development Institute:

cc-TDI, ( www.cc-tdi.org ) is a unique non-profit organization focused on the ‘preclinical gap’ in childhood cancer research. Our mission is to bridge scientific discovery and the initiation of clinical trials. Through our efforts, we will provide evidence-based testing for the selection of new drugs to be used in childhood cancer clinical trials, thus seeding pediatric Phase I and II trials. Our longstanding work with mouse models of brain tumors and sarcomas is the cornerstone for basic science & target discovery and our mission. The cc-TDI research team is led by Scientific Director Dr. Charles Keller who follows in the footsteps of his mentor, 2007 Nobel laureate Mario Capecchi. The cc-TDI laboratory is based on the premise of a non-profit multidisciplinary biotech and is thus located in between the Silicon Forest in Beaverton, OR (Intel Headquarters) and the Portland-area medical center. Our industrial-modern wet lab facility is a former 70-year old paint factory remodeled by Nike as an off-site creative space - an ideal setting to spark innovation.

Press Contact:

Charles Keller MD

Scientific Director

Email:

Official Homepage: www.cc-tdi.org

Twitter: cctdilab

Facebook: cctdilab

Instagram: cctdi

LinkedIn: Children’s Cancer Therapy Development Institute

SOURCE: Champions Oncology, Inc.

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