miRagen Presents Preclinical Data in Pulmonary Fibrosis Using Second Generation microRNA-29 Replacement Product Candidate at the 2019 American Thoracic Society International Conference
BOULDER, Colo., May 21, 2019 (GLOBE NEWSWIRE) -- miRagen Therapeutics, Inc. (NASDAQ: MGEN), a clinical-stage biopharmaceutical company focused on the discovery and development of RNA-targeted therapies, announced today that it will report new data demonstrating that systemic administration of its second-generation microRNA-29 mimic, the Company’s pre-clinical micro-RNA targeted therapeutic candidate for idiopathic pulmonary fibrosis (“IPF”), efficiently reduced extracellular matrix deposition in a series of preclinical studies. The data will be presented today at the 2019 American Thoracic Society (“ATS”) Conference in Dallas, TX.
“We are encouraged by the data presented from several in vivo studies of our second-generation microRNA-29 mimic. These data demonstrate efficacy in blunting the fibrotic response in the bleomycin model of pulmonary fibrosis in mice,” said Paul Rubin, M.D., Executive Vice President, R&D, of miRagen Therapeutics. “Considering the data from these studies, we believe that our lead compound has the potential to be efficacious in the treatment of IPF when administered systemically at considerably lower doses compared to other compounds we have tested in previous pre-clinical studies.”
“These data coupled with previous observations in humans with IPF support the role of microRNA-29 in pathologic fibrosis, as well as the use of microRNA-29 replacements as potential therapeutics in pulmonary fibrosis. I am very excited about the potential role of miRagen’s microRNA-29 mimics, which is being facilitated by our collaboration through the NIH-NHLBI funded CADET program,” stated Naftali Kaminski, M.D., Boehringer-Ingelheim Endowed Professor of Internal Medicine, Chief of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine.
In these studies, a chemically modified microRNA-29 replacement was studied in mice with bleomycin-induced fibrosis in their lungs, which is a well-established model of IPF. The compound was evaluated in both therapeutic and prophylactic dosing paradigms. Data from the studies demonstrated a down-regulation of certain pro-fibrotic genes that were previously established as targets of microRNA-29. These effects extended to downstream targets involved in the pro-fibrotic response, including connective tissue growth factor (CTGF). The downregulation of these mechanistic biomarkers translated to the significant inhibition of the pro-fibrotic response as measured by quantitative histopathological analyses of whole lung scans. This resulted in an approximately 50% inhibition of collagen deposition. Additionally, animals treated with the compound showed normal alveoli architecture, which was not present in control mice.
The poster will be available on the scientific publications page of the Company’s website ( click here ) following the presentation at the 2019 ATS Conference.
About microRNA-29microRNA-29 is a fibroblast-enriched miRNA family that is downregulated in fibrotic diseases, including IPF in humans, thereby leading to a coordinate increase of many extracellular matrix genes. microRNA-29 family targets multiple extracellular matrix proteins and profibrotic molecules. Remlarsen, a first-generation microRNA-29 mimic, has been observed to prevent fibrotic activity in human skin but is not optimized for systemic delivery.
About miRagen Therapeutics, Inc.miRagen Therapeutics, Inc. is a clinical-stage biopharmaceutical company discovering and developing proprietary RNA-targeted therapies with a specific focus on microRNAs and their role in diseases where there is a high unmet medical need. miRagen has three clinical stage product candidates, cobomarsen, remlarsen, and MRG-110. miRagen’s clinical product candidate for the treatment of certain cancers, cobomarsen, is an inhibitor of microRNA-155, which is found at abnormally high levels in malignant cells of several blood cancers, as well as certain cells involved in inflammation. miRagen’s clinical product candidate for the treatment of pathological fibrosis, remlarsen, is a replacement for microRNA-29, which is found at abnormally low levels in a number of pathological fibrotic conditions, including cutaneous, cardiac, renal, hepatic, pulmonary and ocular fibrosis, as well as systemic sclerosis. MRG-110, an inhibitor of microRNA-92, is being developed under a license and collaboration agreement with Servier for the treatment of heart failure and other ischemic disease. In addition to these programs, miRagen is developing a pipeline of preclinical product candidates. The goal of miRagen’s translational medicine strategy is to progress rapidly to first-in-human studies once it has established the pharmacokinetics, pharmacodynamic, safety and manufacturability of the product candidate in preclinical studies. For more information, please visit www.miragen.com.
For information on clinical trials please visit www.clinicaltrials.gov.
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